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2'-NH₂-cAMP

2'- Amino- 2'- deoxyadenosine- 3', 5'- cyclic monophosphate ( 2'-NH₂-cAMP ), sodium salt
Cat. No.: A 088
    
CAS No.: [85819-83-6]
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Product Name Price (net) Qty
Cat. No.: A 088-05
Unit: 5 µmol / ~1.8 mg
$207.00
Sodium salt, for other salt forms please inquire. 2'-NH2-cAMP has a reactive amino group suitable for modification with fluorophores and other markers or spacers and can be used as ligand for affinity chromatography of cAMP and cGMP binding proteins that do not require an intact 2'-OH group. Detailed technical information available. Reference: Jäger et al., J. Biol. Chem., 287, 1210 - 1219 (2012).
Cat. No. A 088
CAS number [85819-83-6]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₂N₆O₅P · Na
Molecular weight [g/mol] 350,2
Modifications 2'-cAMP
Target PKA (cAK) Activator
Lipophilicity 0.85
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
  • 1. Schwede F., Bertinetti D., Langerijs C. N., Hadders M. A., Wienk H., Ellenbroek J. H., de Koning E. J. P., Bos J. L., Herberg F. W., Genieser H.-G., Janssen R. A.Rehmann H., PLoS Biol., 13, 1 - 26 (2015), "Structure-Guided Design of Selective Epac1 and Epac2 Agonists"
  • 2. Jäger R., Russwurm C., Schwede F., Genieser H.-G., Koesling D.Russwurm M., J. Biol. Chem., 287, 1210 - 1219 (2012), "Activation of PDE10 and PDE11 Phosphodiesterases"