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2'-Fluo-AHC-cAMP

2'- (6- [Fluoresceinyl]aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate ( 2'-Fluo-AHC-cAMP ), sodium salt
Fluorescent, PKA-inactive cyclic AMP analogue
Cat. No.: F 003
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: F 003-01
Unit: 1 µmol / ~0.9 mg
$165.00
For other salt forms or metabolites please inquire. Fluorescent cAMP analogue, λexc 494 nm, λem 517 nm. Suitable for phosphodiesterase studies. Detailed technical information available. For reference compare: Schafer et al., Br. J. Pharmacol., 159, 842 - 855 (2010).
Cat. No. F 003
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₃₈H₃₅N₇O₁₃P · Na
Molecular weight [g/mol] 851,7
Modifications 2'-cAMP
Excitation max [nm] 494
Emission max [nm] 517
Absorption max [nm] ~494
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] ~79000
UV pH value 9
  • 1. Schafer P. H., Parton A., Gandhi A. K., Capone L., Adams M., Wu L., Bartlett J. B., Loveland M. A., Gilhar A., Cheung Y.-F., Baillie G. S., Houslay M. D., Man H.-W., Muller G. W.Stirling D. I., Br. J. Pharmacol., 159, 842 - 855 (2010), "Apremilast, a cAMP Phosphodiesterase-4 Inhibitor, Demonstrates Anti-Inflammatory Activity in vitro and in a Model of Psoriasis"
  • 2. Huang W., Zhang Y.Sportsman R., J. Biomol. Screen., 7, 215 - 222 (2002), "A Fluorescence Polarization Assay for Cyclic Nucleotide Phosphodiesterases"