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2'-F-dATP

2'- Deoxy- 2'- fluoroadenosine- 5'- O- triphosphate ( 2'-F-dATP ), sodium salt
ATP analogue for receptor mapping studies
Cat. No.: D 074
    
CAS No.: [73449-07-7]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: D 074-05
Unit: 5 µmol / ~2.5 mg
$260.00

For other salt forms or a guaranteed higher purity please inquire. Analogue of ATP for receptor mapping. 2’-F-ATP can substitute for dATP using DNA polymerase α and γ, but not DNA polymerase β. Detailed technical information available. References: Parker et al., Mol. Pharmacol., 34, 485 - 491 (1988); Ono et al., Nucleic Acids Res., 25, 4581 - 4588 (1997); Richardson et al., Biochem. Pharmacol., 59, 1045 - 1052 (2000).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. D 074
CAS number [73449-07-7]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₅FN₅O₁₂P₃ (free acid)
Molecular weight [g/mol] 509,2 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
  • 1. Richardson F. C., Kuchta R. D., Mazurkiewicz A.Richardson K. A., Biochem. Pharmacol., 59, 1045 - 1052 (2000), "Polymerization of 2'-Fluoro- and 2'-O-Methyl-dNTPS by Human DNA Polymerase Alpha, Polymerase Gamma, and Primase"
  • 2. Ono T., Scalf M.Smith L. M., Nucleic Acids Res., 25, 4581 - 4588 (1997), "2'-Fluoro Modified Nucleic Acids: Polymerase-directed Synthesis, Properties and Stability to Analysis by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry"
  • 3. Parker W. B., Bapat A. R., Shen J. X., Townsend A. J.Cheng Y.-C., Mol. Pharmacol., 34, 485 - 491 (1988), "Interaction of 2-Halogenated dATP Analogs (F, Cl, and Br) with Human DNA Polymerases, DNA Primase, and Ribonucleotide Reductase"