0 Items - $0.00
Categories
A to Z

Alternative structural projections:

2'-dcGMP

2'- Deoxyguanosine- 3', 5'- cyclic monophosphate (2'-dcGMP), sodium salt
PKG-inactive cyclic GMP analogue
Cat. No.: D 020
    
CAS No.: [93919-42-7]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: D 020-10
Unit: 10 µmol / ~3.5 mg
$104.00
For other salt forms please inquire. Protein kinase G inactive analogue of cyclic GMP with modified 2'- moiety for cGMP receptor mapping studies. Detailed technical information available. Reference: Hebert et al., J. Biol. Chem., 273, 5557 - 5565 (1998).
Cat. No. D 020
CAS number [93919-42-7]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₁N₅O₆P · Na
Molecular weight [g/mol] 351,2
Modifications 2'-cGMP
Lipophilicity 1.25
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 13500
  • 1. Jäger R., Russwurm C., Schwede F., Genieser H.-G., Koesling D.Russwurm M., J. Biol. Chem., 287, 1210 - 1219 (2012), "Activation of PDE10 and PDE11 Phosphodiesterases"
  • 2. Werner K., Schwede F., Genieser H.-G., Geiger J.Butt E., Naunyn Schmiedebergs Arch. Pharmacol., 384, 169 - 176 (2011), "Quantification of cAMP and cGMP Analogs in Intact Cells: Pitfalls in Enzyme Immunoassays for Cyclic Nucleotides"
  • 3. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 4. Matthiesen K.Nielsen J., Biochem. J., 423, 401 - 409 (2009), "Binding of Cyclic Nucleotides to Phosphodiesterase 10A and 11A GAF Domains Does Not Stimulate Catalytic Activity"
  • 5. Muhonen W. W.Shabb J. B., Protein Sci., 9, 2446 - 2456 (2000), "Resonant Mirror Biosensor Analysis of Type I(Alpha) cAMP-dependent Protein Kinase B Domain-Cyclic Nucleotide Interactions"
  • 6. Hebert M. C., Schwede F., Jastorff B.Cote R. H., J. Biol. Chem., 273, 5557 - 5565 (1998), "Structural Features of the Noncatalytic cGMP Binding Sites of Frog Photoreceptor Phoshodiesterase Using cGMP Analogs"
  • 7. Schwede F., Ph.D. Thesis, 0, 0 - 0 (1996), "Synthese und Eigenschaften ausgewählter Analoga von cGMP und ihr Einsatz in der biologischen Forschung"
  • 8. Newton R. P., Salih S. G.Khan J. A., Cyclic Nucleotide Phosphodiesterases: Structure M.D. Houslay ed., Wiley Interscience Chichester UK, 17, 141 - 159 (1990), "Cyclic CMP-Specific Phosphodiesterase Activity"
  • 9. Tanaka J. C., Eccleston J. F.Furman R. E., Biochemistry, 28, 2776 - 2784 (1989), "Photoreceptor Channel Activation by Nucleotide Derivatives"
  • 10. Caretta A.Saibil H., J. Cell Biol., 108, 1517 - 1522 (1989), "Visualization of Cyclic Nucleotide Binding Sites in the Vertebrate Retina by Fluorescence Microscopy"
  • 11. Erneux C.Miot F., Methods Enzymol., 159, 520 - 530 (1988), "Cyclic Nucleotide Analogs Used to Study Phosphodiesterase Catalytic and Allosteric Sites"
  • 12. Corbin J. D., Oegreid D., Miller J. P., Suva R. H., Jastorff B.Doeskeland S. O., J. Biol. Chem., 261, 1208 - 1214 (1986), "Studies of cGMP Analog Specificity and Function of the Two Intrasubunit Binding Sites of cGMP-dependent Protein Kinase"
  • 13. Zimmerman A. L., Yamanaka G., Eckstein F., Baylor D. A.Stryer L., Proc. Natl. Acad. Sci. USA, 82, 8813 - 8817 (1985), "Interaction of Hydrolysis-resistant Analogs of Cyclic GMP with the Phosphodiesterase and Light - sensitive Channel of Retinal Rod Outer Segments"
  • 14. Erneux C., Couchie D., Dumont J. E.Jastorff B., Adv. Cyclic Nucleotide Protein Phosphorylation Res., 16, 107 - 118 (1984), "Cyclic Nucleotide Derivatives as Probes of Phosphodiesterase Catalytic and Regulatory sites"
  • 15. Couchie D., Petridis G., Jastorff B.Erneux C., Eur. J. Biochem., 136, 571 - 575 (1983), "Characterization of Phosphodiesterase Catalytic Sites by Means of Cyclic Nucleotide Derivatives"
  • 16. Van Haastert P. J. M., Jastorff B., Pinas J. E.Konijn T. M., J. Bacteriol., 149, 99 - 105 (1982), "Analogs of Cyclic AMP as Chemoattractants and Inhibitors of Dictyostelium Chemotaxis"
  • 17. Zimmerman T. P., Biochem. Pharmacol., 28, 2533 - 2539 (1979), "Nucleoside 3',5'- Cyclic Monophosphate Metabolites of Purine Analogs"
  • 18. Miller J. P., Boswell K. H., Mian A. M., Meyer R. B., Robins R. K.Khwaja T. A., Biochemistry, 15, 217 - 223 (1976), "2'- Derivatives of Guanosine and Inosine Cyclic 3', 5'- Phosphates. Synthesis, Enzymic Activity, and the Effect of 8- Substituents"
  • 19. Garbers D. L., Suddath J. L.Hardman J. G., BBA, 377, 174 - 185 (1975), "Enzymatic Formation of Inosine 3', 5'-Monophosphate and of 2'-Deoxyguanosine 3', 5'-Monophosphate - Inosinate and Deoxyguanylate Cyclase Activity"
  • 20. Drummond G. I., Gilgan M. W., Reiner E. J.Smith M., J. Am. Chem. Soc., 86, 1626 - 1630 (1964), "Deoxyribonucleoside- 3', 5' Cyclic Phosphates. Synthesis and Acid-catalyzed and Enzymic Hydrolysis"