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2-Cl-ATP

2- Chloroadenosine- 5'- triphosphate ( 2-Cl-ATP ), sodium salt
Cat. No.: C 039
    
CAS No.: [49564-60-5]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: C 039-05
Unit: 5 µmol / ~2.7 mg
$160.00

For other salt forms or a guaranteed higher purity please inquire. P2Y purinoceptor agonist. Inhibits soluble guanylate cyclase. Detailed technical information available. Reference: Ruiz-Stewart et al., Eur. J. Biochem., 269, 2186 - 2193 (2002).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. C 039
CAS number [49564-60-5]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₅ClN₅O₁₃P₃ (free acid)
Molecular weight [g/mol] 541,6 (free acid)
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14300
  • 1. Chen L. S.Sheppard T. L., J. Biol. Chem., 279, 40405 - 40411 (2004), "Chain Termination and Inhibition of Saccharomyces cerevisiae Poly(A) Polymerase by C-8-modified ATP Analogs"
  • 2. Ruiz-Stewart I., Kazerounian S., Pitari G. M., Schulz S.Waldman S. A., Eur. J. Biochem., 269, 2186 - 2193 (2002), "Soluble Guanylate Cyclase is Allosterically Inhibited by Direct Interaction with 2-substituted Adenine Nucleotides"
  • 3. Picher M., Sevigny J., D'Orleans-Juste P.Beaudoin A. R., Biochem. Pharmacol., 51, 1453 - 1460 (1996), "Hydrolysis of P2-Purinoreceptor Agonists by a Purified Ectonucleotidase from the Bovine Aorta, the ATP-Diphosphohydrolase"
  • 4. Kwiatkowski A. P.King M. M., Biochemistry, 26, 7636 - 7640 (1987), "Mapping of the Adenosine 5'-Triphosphate Binding Site of Type II Calmodulin-Dependent Protein Kinase"
  • 5. Burnstock G., Cusack N. J., Hills J. M., MacKenzie I.Meghji P., Br. J. Pharmacol., 79, 907 - 913 (1983), "Studies on the Stereoselectivity of the P2-Purinoceptor"
  • 6. Cusack N. J.Hourani S. M. O., Br. J. Pharmacol., 76, 221 - 227 (1982), "Adenosine 5'-Diphosphate Antagonists and Human Platelets: No Evidence that Aggregation and Inhibition of Stimulated Adenylate Cyclase are Mediated by Different Receptors"