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2-Cl-Ado / 2-CADO

2- Chloroadenosine ( 2-Cl-Ado / 2-CADO )
Selective A (1) adenosine receptor agonist
Cat. No.: C 017
    
CAS No.: [146-77-0]
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Product Name Price (net) Qty
Cat. No.: C 017-100
Unit: 100 µmol / ~30 mg
$48.00
Non-metabolizable, selective A (1) adenosine receptor agonist and useful as starting structure for nucleosides and nucleotides modified in position 2 of the purine nucleobase. Detailed technical information available. References: Evans et al., Neurosci. Lett., 83, 287 - 292 (1987); Bellezza et al., Curr. Pharmaceut. Anal., 1, 265 – 272 (2005). This compound is also part of the Ko-Libri compound library (K 001)
Cat. No. C 017
CAS number [146-77-0]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₂ClN₅O₄
Molecular weight [g/mol] 301,7
Absorption max [nm] 263
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14000
  • 1. Lokshin A., Raskovalova T., Huang X. J., Zacharia L. C., Jackson E. K.Gorelik E., Cancer Res., 66, 7758 - 7765 (2006), "Adenosine-mediated Inhibition of the Cytotoxic Activity and Cytokine Production by Activated Natural Killer Cells"
  • 2. Long M. C.Parker W. B., Biochem. Pharmacol., 71, 1671 - 1682 (2006), "Structure-activity Relationship for Nucleoside Analogs as Inhibitors or Substrates of Adenosine Kinase from Mycobacterium Tuberculosis I. Modifications to the Adenine Moiety"
  • 3. Ceruti S., Beltrami E., Matarrese P., Mazzola A., Cattabeni F., Malorni W.Abbracchio M. P., Mol. Pharmacol., 63, 1437 - 1447 (2003), "A Key Role for Capase-2 and Caspase-3 in the Apoptosis Induced by 2-chloro-2'-deoxy-adenosine (Cladribine) and 2-chloro-adenosine in Human Astrocytoma Cells"
  • 4. Ceruti S., Mazzola A., Beltrami E., Passera D., Piantoni E., Cattabeni F.Abbracchio M. P., Drug Dev. Res., 58, 396 - 404 (2003), "Intracellular Phosphorylation of Chloro-adenosine Analogs is a Prerequisite for Activation of Caspase-3 and Induction of Apoptosis in Human Astrocytoma Cells"
  • 5. Abdel-Hamid M., Novotny L.Hamza H., J. Pharmaceut. Biomed. Anal., 22, 745 - 755 (2000), "Stability Study of Selected Adenosine Nucleosides Using LC and LC/MS Analyses"
  • 6. Krass J. D., Jastorff B.Genieser H.-G., Anal. Chem., 69, 2575 - 2581 (1997), "Determination of Lipophilicity by Gradient Elution High-Performance Liquid Chromatography"
  • 7. Shugar D., Acta Biochim. Polon., 43, 9 - 24 (1996), "The NTP Phosphate Donor in Kinase Reactions: Is ATP a Monopolist?"
  • 8. Coomber D. W. J., O'Sullivan W. J.Gero A. M., Int. J. Parasitol., 24, 357 - 365 (1994), "Adenosine Analogues as Antimetabolites against Plasmodium Falciparum Malaria"
  • 9. Shinozuka K., Kobayashi Y., Shimoura K.Hattori K., Nucleosides Nucleotides, 10, 1165 - 1167 (1991), "Regional Difference of Purinergic Modulation on Adrenergic Neurotransmission in Isolated Rabbit Pulmonary Artery"
  • 10. Ribeiro J. A.Monteiro E. C., Nucleosides Nucleotides, 10, 945 - 953 (1991), "On the Adenosine Receptor Involved in the Excitatory Action of Adenosine on Respiration: Antagonist Profile"
  • 11. Fredholm B. B., Ballarin M., Gerwins P., Hu P.-S., van der Ploeg I.Parkinson F., Nucleosides Nucleotides, 10, 955 - 964 (1991), "Pharmacological Implications of a Multiplicity of Adenosine Actions in the CNS"
  • 12. Viswanadhan V. N., Ghose A. K.Weinstein J. N., Biochim. Biophys. Acta, 1039, 356 - 366 (1990), "Mapping the Binding Site of the Nucleoside Transporter Protein: A 3D-QSAR Study"
  • 13. Evans M. C., Swan J. H.Meldrum B. S., Neurosci. Lett., 83, 287 - 292 (1987), "An Adenosine Analogue, 2-Chloroadenosine, Protects against Long Term Development of Ischaemic Cell Loss in the Rat Hippocampus"
  • 14. Maling S. J., Eaton M. A. W., Goodchild J.Stebbing N., J. Appl. Biochem., 2, 130 - 137 (1980), "Hypotensive Effect if Inosine and Related Compounds in Normotensive and Hypertensive Rats"
  • 15. Maguire M. H., Penglis-Caredes F.Gough G. R., Experientia, 30, 922 - 924 (1974), "Effects of the 3', 5'- Cyclic Phosphates of 2- Methylthioadenosine, 2- Chloroadenosine and Adenosine on Platelet Aggregation"
  • 16. Maguire M. H., Penglis-Caredes F.Gough G. R., Experientia, 30, 922 - 924 (1974), "Effects of the 3', 5'- Cyclic Phosphates of 2- Methylthioadenosine, 2- Chloroadenosine and Adenosine on Platelet Aggregation"