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2'-Biotin-16-c-diGMP

2'- O- (6- (6- [Biotinyl]aminohexanoyl)aminohexylcarbamoyl)- cyclic diguanosine monophosphate ( 2'-Biotin-16-c-diGMP / 2'-[Biotin]-AHC-c-diGMP ), sodium salt

Biotinylated analogue of the bacterial second messenger c-diGMP
Cat. No.: B 098
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: B 098-001
Unit: 0.1 µmol / ~0.1 mg
$273.00
For other salt forms please inquire. The biotin label is connected to one of the two ribose 2'-hydroxy groups in c-diGMP (Cat. No. C 057) via a 16 atom spacer. Potential tracer in immunoassays, for affinity chromatography or pull-down assays. The dibiotinylated analogue 2',2''-Di-[Biotin]-AHC-c-diGMP (Cat. No. D 111) is available as well. Detailed technical information available. Reference: Luo, Y. et al., Mol. Biosyst., 8, 772 - 778 (2012).
Cat. No. B 098
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₄₃H₆₃N₁₅O₁₈P₂S (free acid)
Molecular weight [g/mol] 1172,1 (free acid)
Absorption max [nm] 253
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 23700
  • 1. Abdul-Sater A. A., Grajkowski A., Erdjument-Bromage H., Plumlee C., Levi A., Schreiber M. T., Lee C., Shuman H., Beaucage S. L.Schindler C., Microbes Infect., 14, 188 - 197 (2012), "The Overlapping Host Reponses to Bacterial Cyclic Dinucleotides"
  • 2. Luo Y., Zhou J., Watt S. K., Lee V. T., Dayie T. K.Sintim H. O., Mol. Biosyst., 8, 772 - 778 (2012), "Differential Binding of 2'-Biotinylated Analogs of c-di-GMP with c-di-GMP Riboswitches and Binding Proteins"