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Alternative structural projections:

2'-AHC-cGMP

2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphate ( 2'-AHC-cGMP )
Functionalized cGMP for immobilization or conjugation with markers and dyes
Cat. No.: A 048
    
CAS No.: [1262749-60-9]
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Product Name Price (net) Qty
Cat. No.: A 048-05
Unit: 5 µmol / ~2.4 mg
$144.00

Cyclic GMP analogue suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases) or for coupling of various labelling structures including fluorophores. This structure is also offered as a ligand immobilized to agarose (Cat. No. A 059) and with a shorter spacer (2'-AEC-cGMP, Cat. No. A 075). For a corresponding PDE-stable phosphorothioate (Sp-2'-AHC-cGMPS) please refer to Cat. No. A 067. Detailed technical information available. Compare: Corrie et al., Prot. Expr. Purif., 3, 417 - 420 (1992).

Cat. No. A 048
CAS number [1262749-60-9]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₇H₂₆N₇O₈P
Molecular weight [g/mol] 487,4
Modifications 2'-cGMP
Lipophilicity 0.80
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 13500
  • 1. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"