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Alternative structural projections:

2-AHA-cAMP-Agarose

2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel ( 2-AHA-cAMP-Agarose )
Cyclic AMP immobilized on agarose gel
Cat. No.: A 054
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 054-06
Unit: 0.6 ml
$248.00
Cat. No.: A 054-25
Unit: 2.5 ml
$774.00
Cat. No.: A 054-60
Unit: 6 ml
$1,559.00

The second messenger cyclic AMP immobilized on agarose by an aminohexylamino spacer attached to position 2 of the ligand. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. This ligand is also offered with a shorter spacer (2-AEA-cAMP-Agarose, Cat. No. A 110) and as PDE-resistant version (Sp-2-AHA-cAMPS-Agarose, Cat. No. A 069). Detailed technical information available. References: Scholten et al., J. Proteome Res., 5, 1435 - 1447 (2006); Margarucci et al., Mol. BioSyst., 7, 2311 - 2319 (2011); Hanke et al., N. Biotechnol., 28, 294 - 301 (2011).  Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.

Cat. No. A 054
CAS number [pending]
Storage temperature 4°C / 39°F
Modifications 2-cAMP
  • 1. Donaldson L.Meier S., Methods Mol. Biol., 1016, 155 - 173 (2013), "An Affinity Pull-Down Approach to Identify the Plant Cyclic Nucleotide Interactome"
  • 2. Hanke S. E., Bertinetti D., Badel A., Schweinsberg S., Genieser H.-G.Herberg F. W., N. Biotechnol., 28, 294 - 301 (2011), "Cyclic Nucleotides as Affinity Tools: Phosphorothioate cAMP Analogues Adress Specific PKA Subproteomes"
  • 3. Margarucci L., Roest M., Preisinger C., Bleijerveld O. B., van Holten T. C., Heck A. J. R.Scholten A., Mol. Biosyst., 7, 2311 - 2319 (2011), "Collagen Stimulation of Platelets Induces a Rapid Spatial Response of cAMP and cGMP Signaling Scaffolds"
  • 4. Scholten A., Poh M. K., Vandekerckhove J., van Breukelen B., Vos M. A.Heck A. J. R., J. Proteome Res., 5, 1435 - 1447 (2006), "Analysis of the cGMP/cAMP Interactome Using a Chemical Proteomics Approach in Mammalian Heart Tissue Validates Sphingosine Kinase Type 1-interacting Protein as a Genuine and Highly Abundant AKAP"