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2-AHA-cAMP

2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 2-AHA-cAMP )
cyclic AMP functionalized for conjugation with markers and dyes or for immobilization
Cat. No.: A 053
    
CAS No.: [214276-80-9]
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Product Name Price (net) Qty
Cat. No.: A 053-05
Unit: 5 µmol / ~2.2 mg
$207.00
Suitable as a ligand in affinity chromatography (2-AHA-cAMP-Agarose; Cat. No. A 054) and for modification with fluorophores and other markers. Detailed technical information available. Reference: Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006). This ligand is also available with a shorter spacer (2-AEA-cAMP; Cat. No. A 097) as well as PDE-resistant form  (Sp-2-AHA-cAMPS, Cat. No. A 068).
Cat. No. A 053
CAS number [214276-80-9]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₂₆N₇O₆P
Molecular weight [g/mol] 443,4
Modifications 2-cAMP
Target PKA (cAK) Activator
Lipophilicity 1.47
Absorption max [nm] 258
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 12600
  • 1. Schweinsberg S., Moll D., Burghardt N. C., Hahnefeld C., Schwede F., Zimmermann B., Drewianka S., Werner L., Kleinjung F., Genieser H.-G., Schuchhardt J.Herberg F. W., Proteomics, 8, 1212 - 1220 (2008), "Systematic interpretation of cyclic nucleotide binding studies using KinetXBase"
  • 2. Dao K. K., Teigen K., Kopperud R. K., Hodneland E., Schwede F., Christensen A. E., Martinez A.Doeskeland S. O., J. Biol. Chem., 281, 21500 - 21511 (2006), "Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition"
  • 3. Moll D., Prinz A., Gesellchen F., Drewianka S., Zimmermann B.Herberg F. W., J. Neural. Transm., 113, 1015 - 1032 (2006), "Biomolecular Interaction Analysis in Functional Proteomics"
  • 4. Hahnefeld C.Herberg F. W., Abstract of the 13th Protein Kinase Symposium p. 14, 0, 12 - 15 (2002), "cAMP-dependent Protein Kinase: cAMP Analog Screening Using Surface Plasmon Resonance and Fluorescent Methods"
  • 5. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"