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Alternative structural projections:

2-AH-cGMP

N2- (6- Aminohexyl)guanosine- 3', 5'- cyclic monophosphate ( 2-AH-cGMP )

Cyclic GMP functionalized for immobilization or conjugation with markers and dyes
Cat. No.: A 055
    
CAS No.: [205368-58-7]
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Product Name Price (net) Qty
Cat. No.: A 055-05
Unit: 5 µmol / ~2.2 mg
$172.00
Suitable as ligand in affinity chromatography of cGMP-binding proteins (compare Cat. No. A 056) and for modification with fluorophores. For the corresponding PDE-resistant phosphorothioate please inquire. Detailed technical information and references available. Reference: Dills et al., Biochemistry 15, 3724 - 3730 (1976), Hebert et al., J. Biol. Chem., 273, 5557 - 5565 (1998).
Cat. No. A 055
CAS number [205368-58-7]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₂₅N₆O₇P
Molecular weight [g/mol] 444,4
Modifications 2-cGMP
Target PKG (cGK) Activator
Lipophilicity 1.26
Absorption max [nm] 254
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
  • 1. Hebert M. C., Schwede F., Jastorff B.Cote R. H., J. Biol. Chem., 273, 5557 - 5565 (1998), "Structural Features of the Noncatalytic cGMP Binding Sites of Frog Photoreceptor Phoshodiesterase Using cGMP Analogs"
  • 2. Dills W. L., Beavo J. A., Bechtel P. J., Myers K. R., Sakai L. J.Krebs E. G., Biochemistry, 15, 3724 - 3731 (1976), "Binding of Adenosine 3', 5'- Monophosphate Dependent Protein Kinase Regulatory Subunit to Immobilized Cyclic Nucleotide Derivatives"