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2',2''-Di-c-didGMP

2'- , 2''- Dideoxy- cyclic diguanosine monophosphate ( 2',2''-Di-c-didGMP ), sodium salt
Analogue of c-diGMP
Cat. No.: D 139
    
CAS No.: [60307-63-3]
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Product Name Price (net) Qty
Cat. No.: D 139-001
Unit: 0.1 µmol / ~66 µg
$235.00
For other salt forms please inquire. 2',2''-Di-c-didGMP is an analogue of the bacterial second messenger c-diGMP (Cat. No. C 057) which selectively binds the c-diGMP class II riboswitch over the class I riboswitch. It can be useful for discriminating between these two classes of c-diGMP-binding RNAs and for studying RNA-based c-diGMP signalling. Detailed technical information available. Reference: Shanahan et al., J. Amer. Chem. Soc., 133, 15578 - 15592 (2011).
Cat. No. D 139
CAS number [60307-63-3]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₂P₂ (free acid)
Molecular weight [g/mol] 658,4 (free acid)
Absorption max [nm] 253
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 23700
  • 1. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., Biochemistry, 52, 365 - 377 (2013), "Identification of c-di-GMP Derivatives Resistant to an EAL Domain Phosphodiesterase"
  • 2. Zhou J., Watt S., Wang J., Nakayama S., Sayre D. A., Lam Y.-F., Lee V. T.Sintim H. O., Bioorg. Med. Chem.,, 21, 4396 - 4404 (2013), "Potent Suppression of c-diGMP Synthesis Via I-Site Allosteric Inhibition of Diguanylate Cyclases with 2'-F-c-diGMP"
  • 3. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., J. Am. Chem. Soc., 133, 15578 - 15592 (2011), "Differential Analogue Binding by Two Classes of C-Di-GMP Riboswitches"